ABSTRACT
Circadian rhythm is mainly regulated by circadian clock genes, which is the result of biological evolution and plays an important role in maintaining the normal structure and function of organisms. When the circadian rhythm is disturbed or out of balance, it will have adverse health consequences. In addition to studies on diseases of nervous system, endocrine system or cardiovascular system, it has been found that circadian rhythm disorder mediated by circadian clock gene also plays a key regulatory role in the occurrence and development of hepatocellular carcinoma, which is a potential diagnostic marker and therapeutic target. In this paper, the research on the role of circadian clock gene in hepatocellular carcinoma in recent years is reviewed, and the research progresis and existing problems of targeting circadian clock gene in the treatment of hepatocellular carcinoma are discussed.